Mechanics of endocytosis under large osmotic pressure

报告题目：Mechanics of endocytosis under large osmotic pressure

报告人：马锐 (耶鲁大学分子生物物理系)

报告时间：2019年10月25日（星期五）上午10:00-11:00

报告邀请人：  施夏清

报告地点：苏州大学本部物理科技楼101

报告摘要：

In this talk, I will discuss membrane deformations powered by a point force under the condition of high pressure and low tension, which is rarely studied but directly relevant for endocytosis in yeast cells with a cell wall. I will show that the force-height relationship of membrane deformations under this condition is drastically different from that under conditions of high tension and low pressure. In addition, the boundary conditions at the attachment points of the membrane with the cell wall have dramatic effects on the force-height relationship. In particular, if the membrane is allowed to freely rotate at the attachment points, proteins that induced membrane curvature can lift the membrane off the cell wall without any external forces. This result is in sharp contrast with the conclusion of a previous study which adopted boundary conditions that fix the angle between the membrane and the cell wall at the attachment points. I will also discuss possible ways to pull the membrane off the cell wall against the high osmotic pressure with a small amount of force that can be provided by actin polymerization.

报告人简介：

2008年7月毕业于吉林大学信息与计算专业数学学士

2014年1月毕业于清华大学高等研究院物理学博士导师欧阳钟灿院士

2014年6月至今耶鲁大学从事博士后研究，目前任助理研究员

2010年9月-2012年9月作为交换研究生访问德国复杂系统物理研究所师从Frank Juelicher教授，研究兴趣为细胞骨架力学，细胞膜力学，以及分子马达的动力学和热力学。